Amlodipine Besylate 10 mg Tab for Blood Pressure Control

Amlodipine besylate, commonly known by its brand name Norvasc, is a medication primarily used to treat high blood pressure (hypertension) and coronary artery disease. The 10 mg tablet is a standard dosage form that has been widely prescribed for patients requiring blood pressure control. Amlodipine belongs to the class of calcium channel blockers, which work by relaxing blood vessels and improving blood flow.

The use of amlodipine besylate in managing hypertension has been extensively studied, with numerous clinical trials demonstrating its efficacy in reducing blood pressure and associated cardiovascular risks. According to the American Heart Association, calcium channel blockers like amlodipine are recommended as first-line treatments for hypertension in certain patient populations, including those with diabetes or kidney disease.

Efficacy and Mechanism of Action

Amlodipine besylate exerts its therapeutic effect by selectively inhibiting the influx of calcium ions into vascular smooth muscle cells and cardiac muscles. This results in vasodilation, which decreases peripheral resistance and lowers blood pressure. The medication has a gradual onset of action, with peak plasma concentrations achieved within 6-12 hours after oral administration.

Clinical studies have shown that amlodipine besylate 10 mg tablets can reduce systolic and diastolic blood pressure by approximately 10-15 mmHg and 8-12 mmHg, respectively, in patients with hypertension. Additionally, long-term treatment with amlodipine has been associated with a reduced risk of cardiovascular events, including myocardial infarction, stroke, and cardiovascular death.

Pharmacokinetics and Dosage

Amlodipine besylate is administered orally, with a recommended starting dose of 5 mg once daily for patients with hypertension. The dosage can be titrated to 10 mg once daily based on individual patient response and tolerability. The 10 mg tablet is a commonly prescribed dosage form, which provides a convenient and effective treatment option for patients requiring blood pressure control.

Adverse Effects and Precautions

Amlodipine besylate 10 mg tablets are generally well-tolerated, but potential side effects include edema, dizziness, headache, and fatigue. Rare but serious adverse effects, such as angioedema and severe hypotension, have been reported. Patients with known hypersensitivity to amlodipine or other calcium channel blockers should avoid using this medication.

Caution should be exercised when co-administering amlodipine with other medications that may interact with its pharmacokinetics or pharmacodynamics. Regular monitoring of blood pressure and potential side effects is essential to optimize treatment outcomes.

Special Populations and Interactions

Amlodipine besylate can be used in patients with renal impairment, but dose adjustments may be necessary. The medication should be used with caution in patients with hepatic impairment, as amlodipine is metabolized by the liver.

Co-administration of amlodipine with other antihypertensive agents, such as beta-blockers or ACE inhibitors, may increase the risk of hypotension or other adverse effects. Grapefruit juice and certain herbal supplements may interact with amlodipine, and patients should be advised to avoid consuming these products.