Entresto, a medication approved by the FDA in 2015, has been a game-changer in the treatment of heart failure. Also known as sacubitril/valsartan, it is a combination of two drugs that work together to help relax blood vessels and improve cardiac function. As with any medication, Entresto can cause side effects, some of which are common and mild, while others can be serious and potentially life-threatening. In this article, we will explore the common and serious side effects of Entresto, as well as provide guidance on what to do if you experience any of them.
To understand the side effects of Entresto, it's essential to know how it works. Entresto is a neprilysin inhibitor and an angiotensin II receptor blocker (ARB). Neprilysin is an enzyme that breaks down certain natural substances in the body, such as natriuretic peptides, which help to relax blood vessels and improve cardiac function. By inhibiting neprilysin, Entresto increases the levels of these beneficial peptides, leading to improved heart function and reduced symptoms of heart failure. The valsartan component of Entresto blocks the action of angiotensin II, a potent vasoconstrictor that can increase blood pressure and worsen heart failure.
Common Side Effects of Entresto
Common side effects of Entresto are generally mild and temporary. They may include:
- dizziness or lightheadedness (reported in approximately 12% of patients)
- headache (reported in around 7% of patients)
- fatigue or tiredness (reported in about 6% of patients)
- cough (reported in around 5% of patients)
- nausea or vomiting (reported in approximately 4% of patients)
These side effects are usually mild and resolve on their own within a few days of starting treatment. However, if they persist or worsen, it's essential to talk to your doctor.
Serious Side Effects of Entresto
While rare, Entresto can cause serious side effects, some of which can be life-threatening. These include:
- angioedema, a rare but potentially life-threatening allergic reaction characterized by swelling of the face, lips, tongue, or throat (reported in approximately 0.1% of patients)
- hypotension, or low blood pressure, which can cause dizziness, fainting, or even shock (reported in around 2% of patients)
- renal impairment or kidney failure, especially in patients with pre-existing kidney disease (reported in approximately 1% of patients)
- hyperkalemia, or high potassium levels, which can cause cardiac arrhythmias or muscle weakness (reported in around 0.5% of patients)
- allergic reactions, such as hives, itching, or difficulty breathing (reported in approximately 0.2% of patients)
If you experience any of these serious side effects, seek medical attention immediately.
| Serious Side Effect | Frequency |
|---|---|
| Angioedema | 0.1% |
| Hypotension | 2% |
| Renal Impairment | 1% |
| Hyperkalemia | 0.5% |
| Allergic Reactions | 0.2% |
Key Points
- Entresto is a medication used to treat heart failure, which can cause side effects, some of which are common and mild, while others can be serious and potentially life-threatening.
- Common side effects of Entresto include dizziness, headache, fatigue, cough, and nausea or vomiting.
- Serious side effects of Entresto include angioedema, hypotension, renal impairment, hyperkalemia, and allergic reactions.
- If you experience any side effects, it's essential to talk to your doctor, especially if they persist or worsen.
- Regular monitoring, including blood work and blood pressure checks, can help identify potential side effects early on.
What to Do If You Experience Side Effects
If you experience any side effects while taking Entresto, it's essential to talk to your doctor right away. They can help you determine the best course of action, which may include adjusting your dosage, switching to a different medication, or providing guidance on how to manage your side effects.
In some cases, your doctor may recommend that you stop taking Entresto if you experience a serious side effect. However, it's essential to follow their guidance and not stop taking the medication without consulting them first.
Conclusion
Entresto is a valuable treatment option for patients with heart failure, but like any medication, it can cause side effects. By understanding the common and serious side effects of Entresto, you can take an active role in managing your treatment and minimizing potential risks. If you have any concerns or questions, be sure to talk to your doctor.
What are the most common side effects of Entresto?
+The most common side effects of Entresto include dizziness or lightheadedness, headache, fatigue or tiredness, cough, and nausea or vomiting.
Can Entresto cause serious side effects?
+Yes, Entresto can cause serious side effects, including angioedema, hypotension, renal impairment, hyperkalemia, and allergic reactions. If you experience any of these side effects, seek medical attention immediately.
What should I do if I experience side effects while taking Entresto?
+If you experience any side effects while taking Entresto, talk to your doctor right away. They can help you determine the best course of action and provide guidance on how to manage your side effects.